Si usted está tomando diazepam junto con otros medicamentos para controlar las convulsiones y tiene un aumento en su frecuencia o severidad, llame a su médico.
Second dose: When demanded, could be administered immediately after a minimum of 4 hr just after First dose; if the next dose is administered, use a new blister pack of diazepam intranasal
stiripentol will lessen the extent or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Intently. Take into account lessening the dose of CYP2C19 substrates, if adverse reactions are skilled when administered concomitantly with stiripentol.
pentobarbital will reduce the level or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
B: Could possibly be satisfactory. Either animal research display no danger but human studies not available or animal experiments showed insignificant pitfalls and human scientific tests finished and showed no possibility.
Oral Remedy and Oral Tablets. Diazepam oral Option or oral tablets shouldn't be taken if you have any of the next disorders.
Reserve concomitant prescribing of those medicine in patients for whom other remedy here choices are inadequate. Restrict dosages and durations to your least expected. Watch intently for indications of respiratory melancholy and sedation.
Advise both of those clients and caregivers about challenges of respiratory depression and sedation when diazepam is employed with opioids; recommend sufferers to not push or run weighty machinery right up until the results of concomitant use Using the opioid have been decided
Instruct people to tell their healthcare supplier When they are breastfeeding or plan to breastfeed; instruct breastfeeding patients to observe their infants for abnormal sedation, lousy feeding and bad excess weight achieve, and to seek health-related notice whenever they recognize these indicators
crofelemer raises amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Crofelemer has the possible to inhibit CYP3A4 at concentrations envisioned from the intestine; unlikely to inhibit systemically because minimally absorbed.
diazepam will increase the stage or impact of isavuconazonium sulfate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Adjunct use, if apprehension, anxiousness or acute stress reactions current before endoscopic treatments
醫學界視苯二氮䓬類藥物較以往常用的巴比妥鹽類藥物更好，因為後者的治療劑量和中毒劑量差距較少（即是稍微過量便容易中毒），且会形成较强的依赖性。過量服用地西泮較不容易引致死亡（不過仍然有人因服用地西泮過量而死亡），但如同時服用其它鎮靜劑或酒類則會增加危險。
Benzodiazepines for instance diazepam are lipophilic and quickly penetrate membranes, thus speedily cross over to the placenta with significant uptake with the drug. Use of benzodiazepines like diazepam in late pregnancy, Particularly substantial doses, may result in floppy infant syndrome.[63] Diazepam when taken late in pregnancy, through the third trimester, will cause a definite risk of the intense benzodiazepine withdrawal syndrome in the neonate with signs and symptoms which includes hypotonia, and reluctance to suck, to apnoeic spells, cyanosis, and impaired metabolic responses to cold worry.